741 Calle Picacho, Santa Fe, NM 87505

Nestled on a full acre in Santa Fe’s sought-after Eastside, this beautifully maintained single-level adobe home—with a detached guest house—offers approximately 4,500 square feet of flexible living space, timeless design, and sweeping views. Built in 1995 by McDowell Builders with architect Lila DeWindt, the main residence features classic Santa Fe elements throughout: painted ceilings with vigas, kiva fireplaces, and a natural flow between indoor and outdoor living areas. The spacious primary suite is a true retreat, complete with a sitting area, private patio, and dual bathrooms for ultimate comfort and privacy. The heart of the home centers around a sunlit living room with northeast-facing mountain views, opening gracefully into a formal dining room that extends to the rear portal—perfect for entertaining or quiet evenings under the stars. The well-appointed kitchen and great room includes a cozy breakfast nook, kiva fireplace, TV viewing area, and abundant storage. A versatile office or flex room, a laundry room and a half bath for guests completes one area of the home, while a privately situated bedroom with full bath provides additional comfort and privacy for an additional family member or out-of-town guest. The detached guest house is ideal for visitors, work, or creative pursuits. It includes its own entrance, a welcoming entry portal, a private bedroom, full bathroom, kitchenette, and a richly appointed library or sitting room. This is a rare opportunity to own a spacious and flexible home in one of Santa Fe’s most desirable neighborhoods—offering classic architecture, serene surroundings, and room to make it your own.