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 Unlike non-benzodiazepine anxiolytics that require weeks, Lorazepam calms hy peractive neural circuits within minutes by potentiating GABA's inhibitory action. Because it undergoes direct glucuronidation, its kinetics are steadier across patients, including those with hepatic comorbidity, and it lacks active metabolites that accumulate unpredictably. In emergencies (e.g., status epilepticus), IV lorazepam's reliable anticonvulsant effect is why ...