Long-term oxycodone use can have profo und effects on both the brain and body. Oxycodone is a powerful opioid pain medication that can lead to changes in brain chemistry, affecting areas responsible for pain perception, pleasure, and reward. Prolonged use can result in tolerance, dependence, and addiction, as the brain adapts to the presence of the drug.

Physically, long-term oxycodone use can lead to a range of adverse effects on the body, includ...