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Opana ER 10 mg is a moderate-strength, extended-release opioid analgesic that contains oxymorphone hydrochloride, a semi-synthetic opioid derived from thebaine, an opium alkaloid. It was manufactured by Endo Pharmaceuticals and approved by the FDA for the long-term treatment of chronic moderate-to-severe pain in opioid-tolerant patients who require 24-hour pain control.